3. Results
During infusions (48 h), the mean insulin infusion rate
after the increase of insulin concentrations by administration
of a bolus of 4 mU/kg BWinsulin solutionwas 0.6mU/kg
BW/min in HypoG and EuG. In EuG, the glucose infusion rate
to keep plasma glucose concentrations at a preinfusion level
was 2.200.04 mmol/kg/min (meanstandard error of the
mean). Insulin infusion caused an increased plasma insulin
AUC/h (Table 1; P < 0.01) at simultaneously decreased
plasma glucose AUC/h (P < 0.01), in HypoG as compared
with plasma insulin and glucose AUC in NaCl. In HypoG,
plasma glucagon AUC/h increased markedly during insulin
infusions as compared with preinfusion levels and
compared with NaCl (Fig. 1; Table 1; P < 0.01). In EuG, the
intravenous insulin administration combined with glucose
infusion caused an increase of plasma insulin AUC/h (P <
0.01) at simultaneously unchanged plasma glucose concentrations.
In contrast to HypoG, the simultaneous infusion
of insulin and glucose in EuG caused a decline of plasma
glucagon concentrations compared with the preinfusion
level and compared with HypoG and NaCl (P < 0.01).