Nematocyst discharge by tubule ejection and delivery of venoms harmful for both preys and predators underlie Cnidarians survival (Fautin, 2009). However, discharge may also provide damage to bathers coming across stinging animals in marine waters. This accidental contact results in painful local and, in several cases, even severe systemic pathological reactions (Tibballs, 2006 and Mariottini and Pane, 2013), thus providing an imperative to study the mechanisms of envenomation after a sting and possible remedies. In this regard, it has been reported that different substances, such as the local anesthetic lidocaine, ethanol, ammonia and acetic acid provide pain relief