When we factored a family history of psychiatric illness or traumatic
childhood experiences into our analysis;we found that WNK1 and Myt1l
SNPs had significant associations with schizophrenia in subjects with a
maternal mental history and childhood trauma respectively. These results
suggest that the genes for the downstream signaling partners of
NgR may play a role in the inheritance of psychiatric disorders. Furthermore,
alterations in brain volumes [19,37,38] and abnormal axonal
connectivity, in particular within the corpus callosum (the highest myelinated
fiber tract in the brain), have been observed in children with a
history of abuse or neglect [3,39–42].