The influence of malaria on hematological parameters is extensively investigated and PCV reduction is considered a hallmark of both human and rodent malaria(reviewed in Lamikanra etal).Infected mice may suffer from severe malarial anemia because of rapid erythrocyte destruction,either by parasitemia and/or spleen reticulo-endothelial cells.For instance,in one study it was noted that within an estimated 48 hrs of post-infection rodent PCV in infected-mice.