Pi stimulates the phosphorylation of Akt1 at Thr308
and downstream signaling pathways such as Raf/MEK/
ERK. Akt1 is an important serine/threonine kinase in the
phosphatidylinositol3-kinase (PI3K) pathway, and it is
involved in cell cycle and apoptosis. Akt regulates cancer cell proliferation through the inhibition of apoptosis