ChonbukNational University Laboratory Animal Center. BALB/c mice (n ¼ 4) were
sensitized by i.p. injection of 50 mg ovalbumin (OVA, SigmaeAldrich) on day 1. On
day 8 and 15 mice were challenged intranasally with 50 mg of OVA.Mice were given
50 mL of POX or HPOC nanoparticles intranasally on days 16 and 17. Control mice
were given PBS only.