Introduction The significance of low-level laser in clinical medicine began with the important works of Endre Mester. The basic science underlying low-level laser therapy (LLLT) is that it involves the treatment of various medical diseases with photomedicine and the use of low-level lasers or light-emitting diodes to alter cellular function, or, in short, the employment of photo-biomodulation effects to help normalize cellular functions, including the energy usage of body cells. In recent years, the various clinical applications of LLLT have mainly been based on previous scientific works concerning the effect of low-level lasers, such as increasing adenosine triphosphate production,1 while, at the same time, the exertion of a positive influence on fibroblast2 and collagen synthesis3 at the cellular-molecular level. Clinical protocols exist for LLLT in the management of common painful conditions such as rheumatoid arthritis, osteoarthritis, acute and chronic neck pain, tendinopathy, and chronic joint disorders.