Differential dynamic potentiometry (DDP) is a novel potentiometric technique, which consists of recording
the dynamic potential difference between two ion-selective electrodes (ISEs). In this article, we
describe its application to studying the dynamic contribution of beta-cyclodextrin (-CD) to the potential
response of drug-selective electrodes. Surprisingly, DDP responses in serial calibration mode were
characteristic for each individual drug, and might serve as drug-fingerprints. Also, non-monotonic DDP
responses were obtained using single concentration step experiments, and these were used for quantitative
drug analysis. Theoretical simulations of the DDP responses based on a reported dynamic diffusion
model allowed both types of the experimentally obtained signals to be predicted.