Although individual phlorotannins contained in the edible brown algae have been reported to possess
strong anti-inflammatory activity , the responsible components of Eisenia bicyclis have yet to be fully studied.
Thus, we evaluated their anti-inflammatory activity via inhibition against production of lipopolysaccharide
(LPS)-induced nitric oxide (NO) and tert-butylhydroperoxide (t-BHP)-induced reactive oxygen
species (ROS), along with suppression against expression of inducible nitric oxide synthase (iNOS), and
cyclooxygenase-2 (COX-2), in RAW 264.7 cells.