perspectives Sarcopenia is one of the most burdensome geriatric syndromes.As such, the development of effective preventive and therapeu-tic measures is urgently needed. This task is hampered by the heterogeneity of clinical correlates of sarcopenia, reflecting the complexity of its pathogenesis. Derangements in mitochondrial function are currently invoked as major factors in the sarcopenia syndrome. Yet, exploiting mitochondrial pathways for therapeu-tic purposes is an ambitious task. First, most processes governing mitochondrial physiology exhibit a “yin-yang behavior”, but the iroptimal range of functioning is currently unclear.