Turbidimetric methodologies were introduced into automated coagulometers in the 1990s
including for example, latex agglutination. Latex particles are coated with an antibody
specific for the analyte of interest. When the particles come into contact with the sample and
recognise the antigen, the sample begins to agglutinate resulting in a change in sample
turbidity and light scattering. The increase in light absorbance is proportional to the level of
agglutination in the sample which is also proportional to the sample antigen concentration