Fumonisins are not easily absorbed by the intestinal wall however they can pass through when tight junction quality is reduced.they are potent inhibitors of ceramide synthase,which influences cell structure and signaling. During ceramide synthase,complex. Sphinganine (SA) and sphingosine (SO). Inhibition of this process causes an elevation of sphinganine concentration in the blood, leading to an increase in the SA/SO ratio is significantly increased by the high mycotoxin level diet,indicating that Fumonisins was taken up by the animal (Figure 3). The inclusion of the “biopolymer’’ in the mycotoxin contaminated diet significantly lowered the SA/SO ratio compared to the mycotoxin group,indicating that addition of the ‘biopolymer’ to the diet is effective in reducing migration of Fumonisins through the intestinal wall. Usually mycotoxins severely reduce feed intake and body weight gain of animals,but in this study it was shown that a blend of a smectite clay binder,immunity supporting components and a specific glucose biopolymer added to feed with very high mycotoxin concentrations is effective in reducing the negative effects of mycotoxins on the growth and performance of broilers.
This is accomplished by boosting the intestinal barrier, leading to a positive effect on animal’s gut health and performance. AAF
References are available on request from the authors