Formulations studied
Formulations were prepared in a Heidolph RZR 2021
(Schwabach, Germany) stirrer at 600 rpm. The gel-cream was
obtained by adding to deionized water the following components
to the final stated percentages (w/w): 5.0% SepigelTM 305,
4.0% NET FSTM, 2.0% glycerin, 0.8% PhenovaTM dissolved in
3.0% propyleneglycol and 0.02% dl--tocopherol as antioxidant.
The gel-cream was supplemented with retinyl palmitate
and tocopheryl acetate to final concentrations of 1% (w/w) and
2% (w/w), respectively.