Resistance to chemical insecticides in other vectors such as Ae. albopictus and Aedes aegypti was also confirmed[9-15]. To face the increasing emergence of mosquito resistance to chemical insecticides, a sound option lays on the use of natural products. In this study, seed extracts of Annona squamosa (A. squamosa) and Annona muricata (A. muricata) were used to control adult mosquitoes as well as larval stages of the vectors Ae. albopictus and Cx. quinquefasciatus. Annonaceae are empirically known to elicit insecticidal activities[12,16]. Plant species in this family contain an array of toxic compounds such as acetogenins, alkaloids, flavonoids that confer to these plants their insecticidal proprieties[12]. Both seeds of A. squamosa and A. muricata contain a great amount of acetogenins[16]. This special group of chemical compounds is known as mitochondrial complex I inhibitor[12,17,18]. Some alkaloids were found in A. muricata. And extracts of A. muricata not only affect the mortality rate of pupal and adult stages of mosquitoes but also reduce the reproductive success of surviving adults by decreasing fecundity and egg hatchability[19]. Petroleum ether leaf extracted from leaves of A. squamosal were reported to possess an insecticidal and growth regulating activities on three mosquito species namely Anopheles stephensi, Cx. quinquefasciatus and Aedes aegypti[19]. The aim of this study was to evaluate the actual efficacy of seed extracts of A. squamosa and A. squamosa under laboratory conditions in order to assess their potential uses as natural insecticides to control adult mosquitoes as well as larval stages of the vectors Ae. albopictus and Cx. quinquefasciatus. A preliminary screening using various micro-reactional techniques and also GC analyses were also performed to identify the range of chemical groups of ingredients in the compositions of the aqueous and oil extracts of the two seeds.