Statistical analysis
Data are expressed as mean ^ SE. All statistical analyses were
done with SAS software version 9.1.3 (SAS Institute, Inc.,
Cary, NC, USA). Data were analysed using a two-way
repeated-measures ANOVA (SAS PROC MIXED) with dose
and time as the fixed effects and subject as the random
effect. The statistical significance for multiple comparisons
was adjusted with respect to the Tukey - Kramer method
The present study was conducted according to the
guidelines laid down in the Declaration of Helsinki, and all
procedures involving human subjects were approved by the
Pennington Biomedical Research Center Institutional Review
Board (#27 034). Written informed consent was obtained
from all subjects.