Anti-Prostatic Hyperplasia activity In other to investigate the effects of methanolic extract of Citrullus lanatus seed (MECLS) on experimentally induced benign prostate hyperplasia, twenty adult male Wistar rats weighing about 135-180g were randomly divided into four groups of five animals each. Group I, which served as normal control (NC) was given corn oil as placebo 1g/kg BW; Group II, served as Hormone treated control (HTC), Groups III, and IV which served as hormone and extract treated (HTEC) received continuous dosage of 300μg and 80μg of testosterone (T) and estradiol (E2) respectively on alternate days for three weeks subcutaneously in the inguinal region while the extract treated received an additional 2g/kg BW (low dose) and 4g/kg BW (high dose) of extract orally for 4 weeks after the successful induction of prostate enlargement. Immediately after induction some animals were randomly selected and sacrificed for gross inspection of prostate enlargement and sperm count evaluation