3.6. Effect of CSP on hepatic and renal function
An excellent chemotherapeutics include not only the virtue of
repressing the growth of malignant cells but also the minimum toxicity
to their normal organs. To examine the potential toxicological
effects of CSP administration on the kidney and liver of the host, we
evaluated their serum renal function markers such as BUN, UA and
CRE, and serum hepatic function markers including ALT and AST. As
shown in Table 4, the increased the levels of serum ALT, AST, BUN,
UA, and CRE were obviously observed in cisplatin group as compared
to the model group (P < 0.05). Allthese indexes were restored
or downregulated after CSP treatment atthree doses, although they
3.6. Effect of CSP on hepatic and renal functionAn excellent chemotherapeutics include not only the virtue ofrepressing the growth of malignant cells but also the minimum toxicityto their normal organs. To examine the potential toxicologicaleffects of CSP administration on the kidney and liver of the host, weevaluated their serum renal function markers such as BUN, UA andCRE, and serum hepatic function markers including ALT and AST. Asshown in Table 4, the increased the levels of serum ALT, AST, BUN,UA, and CRE were obviously observed in cisplatin group as comparedto the model group (P < 0.05). Allthese indexes were restoredor downregulated after CSP treatment atthree doses, although they
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