The current analyses reveal a protective association
between the zinc-to-cadmium ratio (log-transformed)
and reduced respiratory risk suggesting that Zn may
moderate the risk of smoking-associated lung disorders
through interplay with Cd. Zn is essential to the production
of metallothionein, a key component in the detoxification
kinetics of Cd in the human body [13,14].
Metallothionein alone can passively extract the interfering
Cd and reduce its toxic load directly. The inverse
association between Zn and Cd adds support to the
hypothesis that when sufficient Zn is available, metallothionein
not only extracts the offending Cd, but actively
restores structure and function by donating the missing
Zn [37]. Alternatively, the positive influence of Zn may
also result from the anti-inflammatory and anti-oxidant
activities of a spectrum of Zn-dependent enzymes and
transcription factors [38,39]. It was found, for instance,
reported that zinc can decrease the production of inflammatory
cytokines such as tumor necrosis factor-? (TNF-
?) and interleukin-1? (IL-1?) via inhibition of NF-kappaB
activation [38]
The current analyses reveal a protective associationbetween the zinc-to-cadmium ratio (log-transformed)and reduced respiratory risk suggesting that Zn maymoderate the risk of smoking-associated lung disordersthrough interplay with Cd. Zn is essential to the productionof metallothionein, a key component in the detoxificationkinetics of Cd in the human body [13,14].Metallothionein alone can passively extract the interferingCd and reduce its toxic load directly. The inverseassociation between Zn and Cd adds support to thehypothesis that when sufficient Zn is available, metallothioneinnot only extracts the offending Cd, but activelyrestores structure and function by donating the missingZn [37]. Alternatively, the positive influence of Zn mayalso result from the anti-inflammatory and anti-oxidantactivities of a spectrum of Zn-dependent enzymes andtranscription factors [38,39]. It was found, for instance,reported that zinc can decrease the production of inflammatorycytokines such as tumor necrosis factor-? (TNF-?) and interleukin-1? (IL-1?) via inhibition of NF-kappaBactivation [38]
การแปล กรุณารอสักครู่..
![](//thimg.ilovetranslation.com/pic/loading_3.gif?v=b9814dd30c1d7c59_8619)