constriction of the ductus arteriosus (28). A
meta-analysis of neonatal complications after
indomethacin tocolysis revealed no association with
neonatal respiratory distress syndrome or with intraventricular
hemorrhage, but it did reveal an elevated
risk of periventricular leukomalacia (OR 2.0, 95%
CI 1.3–3.1) and early necrotizing enterocolitis (OR
2.2, 95% CI 1.1–4.2) (29).