Discussion
Cancer in various organs increases gradually and, although many patients recover from cancer, it is one of main causes of hu- man death. Anticancer agents are useful for the treatment of cancer but these are associated with various adverse effects. The adverse effects of these anticancer agents on the reproductive system are especially severe, and they are one of the main causes of male sterility. Therefore, much research has been performed to develop functional foods or medicines to alleviate or reduce adverse effects induced by anticancer agents. Previous reports have suggested that the ginseng total saponin fraction attenuated cisplatin-induced nausea and vomiting in animal studies [9,10]. In the present study, we have shown that KRGE attenuated busulfan-induced damage to the male reproductive system. These results indicate that KRGE might have an efficacy for the attenuation of anticancer agent-induced adverse effects and that KRGE might be a novel candidate for developing drugs that reduce the adverse effects induced by busulfan.
DiscussionCancer in various organs increases gradually and, although many patients recover from cancer, it is one of main causes of hu- man death. Anticancer agents are useful for the treatment of cancer but these are associated with various adverse effects. The adverse effects of these anticancer agents on the reproductive system are especially severe, and they are one of the main causes of male sterility. Therefore, much research has been performed to develop functional foods or medicines to alleviate or reduce adverse effects induced by anticancer agents. Previous reports have suggested that the ginseng total saponin fraction attenuated cisplatin-induced nausea and vomiting in animal studies [9,10]. In the present study, we have shown that KRGE attenuated busulfan-induced damage to the male reproductive system. These results indicate that KRGE might have an efficacy for the attenuation of anticancer agent-induced adverse effects and that KRGE might be a novel candidate for developing drugs that reduce the adverse effects induced by busulfan.
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