Isogenic
Isogenic strains (inbred strains and F1 hybrids) have made a substantial contribution to biomedical research. This sub-web describes their properties and characteristics and contrasts them with the genetically heterogeneous “outbred” stocks of mice and rats which are still widely used in biomedical research. It makes the case that the use of outbred stocks should be discontinued unless specifically justified for a particular research application.