Niosomal vesicular systems containing resveratrol, alpha-tocopherol and curcumin as single agents and
in combination, were designed with the aim to develop novel cosmeceutical formulations. The effects
of antioxidants co-encapsulation on the physico-chemical properties of the carriers, their antioxidant
properties and in vitro percutaneous permeation profiles were evaluated. Results showed that the coencapsulation
of resveratrol/curcumin and alpha-tocopherol/curcumin affected the physico-chemical
properties of niosomes and the entrapment efficiencies values, respect to the formulations containing
the single antioxidant. The antioxidants in vitro percutaneous permeations appeared to be controlled
and improved respect to the corresponding free solutions used as control. Moreover the antioxidants
combinations resulted in a promoted ability to reduce free radicals, due to a synergic antioxidant action