Several epidemiological studies have examined the relationship between coffee consumption and coronary heart disease (CHD) risk. In general, case-control studies have found high coffee intakes to be associated with significantly increased risk of CHD or myocardial infarction (MI). Two separate meta-analyses that combined the results of eight case-control studies found that CHD risk was 40–60% higher in those who consumed 5 or more cups of coffee daily compared to those who did not drink coffee