TNF-a is elevated in asthma and is
related to the production of T helper-2 cytokines as IL-4
[48] . There are common genes, playing a role in both asthma
and obesity as chromosomes 5q, 6, 11q13, and 12q [45] .
Adipose tissue contains the enzyme aromatase, which is
responsible for converting androgens into estrogens causing
airway hyper-reactivity and greater severity of irreversible air-flow obstruction