Histopathologic Description:
The section of liver is characterized by marked centrilobular and midzonal hepatic necrosis (Fig. 1-1) with sparing of hepatocytes located adjacent to portal triads. Canalicular plugging with bile is frequently observed between surviving hepatocytes (Fig. 1-2). In the necrotic tissue, ghost-like remnants of necrotic hepatocytes and the accompanying sinusoids can generally be visualized (coagulative necrosis). Inflammatory cell activity is minimal in all areas.