Skeletal muscle tissue is a highly complex organ, and apart for being responsible for generating movement, also serves various other functions (e.g. imports glucose to regulate blood glucose concentration, generate heat, produce inflammatory cytokinase, to name but a few). The primary components of skeletal muscle responsible for generating motion can be subdivided into the contractile proteins and the metabolism that supplies ATP needed for the former. The contractile properties of an individual muscle fiber depend largely on the myosin heavy chain (MHC) isoform it expresses. Three isoforms, namely MHC I, IIa and IIx are commonly expressed in adult mammalian skeletal muscle, including humans