Researched candidates are:
glucocorticoid synthesis inhibitors, antagonists of glucocorticoid
receptors (Mifepristone (RU-486), antagonists
of CRF 1 receptors (Antalarmin). Since the glutamatergic
system is especially involved in pathophysiology of
affective disorder possible therapeutic agents are being
investigated among glutamate receptor modulators,
NMDA antagonists (lamotrigine, riluzole, memantine,
Felbamat, Zinc) and AMPA receptor modulators
(Ampalex)