intragastric pH
was maintained above 4.0 for a mean of 14.0 h with esomeprazole,
12.1 h with rabeprazole, 11.8 h with omeprazole,
11.5 h with lansoprazole, and 10.1 h with pantoprazole (p
0.001 for differences between esomeprazole and all other
comparators). Esomeprazole also provided a significantly
higher percentage of patients with an intragastric pH greater
than 4.0 for more than 12 h relative to the other proton pump
inhibitors (p 0.05).