Doublecortin (DCX) and glial fibrillary acidic protein (GFAP)
expression in the dorsal hippocampus of young, old and senile rats.
Images: Coronal sections of the dentate gyrus in representative
animals of each age group showing DCX(+) neurons (Panels A-C)
and of the stratum radiatum for GFAP (+) cells (Panels E-G). Scale
bars=100 lm for DCX images and 25 lm for GFAP. DCX and GFAP
cell numbers are plotted in Panel D and H, respectively. Note the
sharp age-related fall in DCX cell numbers. Abbreviations: dh
(dentate hilus); gcl (granular cell layer); ml (molecular layer).
Number of young, old and senescent hippocampi assessed for
DCX was 6 for the 3 age groups and was 5, 6 and 5, respectively for
GFAP. Other details are as in Fig. 2. The Holm–Sidak post hoc test
was used for group comparisons in both plots.