The prevalence of T. whipplei bacteremia and associated clinical manifestations needs to be defined thoroughly in various populations (children, adults, and immunocompromised individuals) from different geographical areas. The prevalence of T. whipplei pneumonia [19] and gastroenteritis [15] also needs to be studied in different settings. These studiesmay help to identify the reservoir and mode of transmission of T. whipplei. Although human- to-human transmission is likely, environmental (food, water, and soil) and/ or zoonotic risks should also be searched for.