The RNA molecular basis of violence and pathogenesis of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) that must to know, to ensure that vaccine development precede of dengue virus evolution. The mechanisms of vaccine-induced protection need to be clarified in future. The agreement immunologic target of a neutralizing immunity reaction to all 4 serotypes in at least 80% of volunteers may not be convenient in all community and clinical settings.