The current anti-cancer drugs available in market are not target specific and have been demonstrated to pose several side-effects and complications as compared with natural anticancer materials, which highlight the urgent need for novel effective and less-toxic agents such as from natural products. And numerous side effects of chemo- and radiotherapy require the use of additional remedies to maintain and improve the immune status of patients. For instance, anticancer therapy can include the herbal drugs, especially those have cytotoxic properties with minimal side effects. Such as, medicinal mushrooms and their synthetic derivatives are expected to play an important role in developing innovative agents for prevention of human cancer.