The NS-specific viral RNA segment of influenza A virus encoded for both NS1 and
nuclear export protein (NEP). Unspliced NSspecific mRNA translates into the NS1 protein, while the spliced RNA directs the synthesis of the NEP (O’Neill et al, 1998). Previous studies have indicated that the NS1 gene
functioned as an antagonist against the host
interferon defense system in multiple ways
(Garcia-Sastre et al, 1998).