One of the challenging aspects of managing pediatric
T2D is related to the paucity of data regarding effective
interventions. In a previous study including129 children
with T2D from Germany and Austria, dropout rates from the
program were high and children had relatively high rates of
comorbidities.
39
Recently, the Treatment Options for Type2
diabetes in Adolescents and Youth (TODAY) study reported
its findings.
26,40
This was a large, randomized, prospective
clinical trial in which699 patients aged10–17 years with
T2D were randomized to three treatment choices including
metformin alone, metformin plus intensive lifestyle intervention, and metformin plus rosiglitazone.