It is believed that tension associated with resistance training
disturbs the integrity of skeletal muscle, causing mechanochemically
transduced molecular and cellular responses
in myofibers and satellite cells (182). Upstream signaling is
thought to occur through a cascade of events that involve
growth factors, cytokines, stretch-activated channels, and
focal adhesion complexes (23,48,162). Evidence suggests that
the downstream process is regulated via the AKT/mTOR
pathway, either through direct interaction or by modulating
production of phosphatidic acid (72,73). At this point,
however, research has not provided a clear understanding of
how these processes are carried ou
It is believed that tension associated with resistance trainingdisturbs the integrity of skeletal muscle, causing mechanochemicallytransduced molecular and cellular responsesin myofibers and satellite cells (182). Upstream signaling isthought to occur through a cascade of events that involvegrowth factors, cytokines, stretch-activated channels, andfocal adhesion complexes (23,48,162). Evidence suggests thatthe downstream process is regulated via the AKT/mTORpathway, either through direct interaction or by modulatingproduction of phosphatidic acid (72,73). At this point,however, research has not provided a clear understanding ofhow these processes are carried ou
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