Vaginal Progesterone
to Prevent
Preterm Birth
in High-Risk Women
Conclusions
Th e authors concluded that administration of
vaginal progesterone gel to women with a diagnosed
short cervix of 10 to 20 mm and no
history of a prior preterm birth was associated
with a decreased rate of preterm birth and
neonatal morbidity and mortality. Treatment
with vaginal progesterone gel resulted in a 45
percent decrease in birth prior to 33 weeks. Although
a previous preterm birth increases risk
in subsequent pregnancies (Adams, Elam-Evans,
Wilson, & Gilbertz, 2000; Meis et al., 2003),
nulliparous women cannot be assessed for the
risk of preterm birth based upon history alone.
Th erefore, universal cervical length screening in
mid-pregnancy may help identify asymptomatic
women at risk for preterm birth; and administration
of daily vaginal progesterone gel may be
an eff ective intervention to decrease the rate of
preterm birth and improve neonatal outcomes.
Vaginal Progesterone
to Prevent
Preterm Birth
in High-Risk Women
Conclusions
Th e authors concluded that administration of
vaginal progesterone gel to women with a diagnosed
short cervix of 10 to 20 mm and no
history of a prior preterm birth was associated
with a decreased rate of preterm birth and
neonatal morbidity and mortality. Treatment
with vaginal progesterone gel resulted in a 45
percent decrease in birth prior to 33 weeks. Although
a previous preterm birth increases risk
in subsequent pregnancies (Adams, Elam-Evans,
Wilson, & Gilbertz, 2000; Meis et al., 2003),
nulliparous women cannot be assessed for the
risk of preterm birth based upon history alone.
Th erefore, universal cervical length screening in
mid-pregnancy may help identify asymptomatic
women at risk for preterm birth; and administration
of daily vaginal progesterone gel may be
an eff ective intervention to decrease the rate of
preterm birth and improve neonatal outcomes.
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