Conduct the test of equal variance of the Bartlett’s test for body weight, body weight gain, body temperature, hematology, blood biochemistry, for each value of the weight ratio of the organ weight. Dunnett’s method of parametric type,unequal at the time of the equal variance performing a comparison test for each treatment group and the control group by Steel’s method at the time of dispersion. Also performed using Paired t-test comparison of the values of the time points examined and pre-dose values as needed. Note that the 5% significance level value