Effect of Korean Red Ginseng extract (KRGE) on busulfan-induced decrease of
serum testosterone concentration and litter size. (A) Treatment of mice with busulfan
alone caused a decrease of serum testosterone concentration, whereas pretreatment
with 100 mg/kg KRGE before busulfan treatment significantly restored serum testosterone
concentration (n ¼ 7, *p < 0.05, compared with busulfan alone or 100 mg/kg
KRGE before busulfan treatment). (B) Treatment of mice with busulfan alone caused a
decrease of litter size compared with the control (Con), whereas pretreatment with
200 mg/kg KRGE before busulfan treatment significantly restored litter size (n ¼ 10,
**p < 0.05, compared with busulfan alone).