Some current treatments for T2DM have already been
tested concerning their possible effects in reducing glucose
variability as well as reducing glycated hemoglobin
(HbA1c) [8]. Exercise, which is one of the cornerstones
of treatment for hyperglycemia in T2DM because of its
beneficial effect on HbA1c [9], was recently shown to
reduce glucose variability in addition to its acute effects
on reducing glucose levels [7]. Vildagliptin and sitagliptin
are two drugs that were recently evaluated in a study
focusing on possible differences in daily glucose fluctuations
in patients with T2DM inadequately controlled
with metformin, and it showed that vildagliptin was
more effective in flattening acute glucose fluctuations
over a day [8]. Moreover, acarbose was superior to glibenclamide
in reducing MAGE. Therefore, aside from
their absolute glucose-lowering effect, it is evident that
other effects of different anti-diabetic agents might also
be different [10].