Cavity detection was done by creating expanded van der Waals molecular surfaces on the protein atoms. The protein was covered by a grid of resolution 0.8 Å by placing at every grid point a sphere of radius 1.4 Å to check the overlapping with the van der Waals radii of the protein atoms. The accessible grid points were further checked for its presence in the cavity with a probe size of 1.20 Å for a maximum of 16 ray checks and a minimum of 12 ray hits. Then the grid points were connected for neighbors discarding volumes at below 10.0Å.