In mechanism studies, short periods of hypothermia are usually employed (Nishio et al., 2000; Yunoki et al., 2003); in clinical trials, however, longer durations are considered more effective (Liping Liu and Yenari, 2009; Van der Worp et al., 2010). In summary, the water immersion technique described above offers precise temperature control without repeated animal movement and with continuous physiological monitoring in order to more accurately model the physiological properties and efficacy of therapeutic hypothermia