Due to the widespread distribution of CNS damage in MS, the
deficient integration of these pathways can influence postural
response in maintaining correct balance and consequently predispose
MS patients to fall. Because bone mineral density is reduced in
most MS patients [8], the high incidence of falls increases the risk of
fractures in these subjects, especially those with osteoporosis [8]. A
decrease in mobility is strongly associated with osteoporosis
aggravation and muscle wasting as well as more frequent falls.
Therefore, simply due to a fall, an MS patient may suffer from a
major fracture leading to prolonged bed rest and experience further
loss of bone density and muscle mass worsening the patients'
disability [11].