Secondary caries in the clinical setting may ultimately depend on individual habits and
different patterns of oral pathogens prevalence within the biofilm, whereas the material may
play a smaller role as suggested in the present study. Nonetheless, a different scenario may
be found for secondary caries in the shape of wall lesions, since interfacial gaps and loading
can create distinct niches, which were not present in this study. In this sense, future
research should also focus on secondary caries in interfacial gaps.