Additionally, an interrupted time series (ITS) analysis
on 2-month periods was performed to determine the
longitudinal effects of the hand hygiene education
program on the number of nosocomial bloodstream
infections. The guidelines of the ORION statement were
adhered to Cooper et al. (2007). Subsequent nosocomial
bloodstream infections in the same patient were defined as
another infection when it was caused by another pathogen
according to the antibiogram of the same microorganism
in combination with a re-elevation of the C-reactive
protein concentration