Conclusions
Lung cancer detected at the time of or after lung
transplantation carries various clinical courses. Patients
with metastasis have poor survival and significant toxicities
from chemotherapy, but variability in outcome still remains.
Early stage patients and those with lung cancer in explanted
lungs should be considered for treatment with a curative
intent, but modified and dose-reduced regimens along with
prophylactic antibiotics are highly encouraged to decrease
the chance of severe adverse events, including profound
neutropenia and sepsis.