• Inhibition of peripheral blood hematopoietic
Progenitors
• Anemia
Amphotericin B • Anemia • Myelosuppression
• Thrombocytopenia
• Leukopenia
Chemotherapy • Granulocytopenia • Myelosuppression
Doxorubicin
Bleomycin
Vincristine
Flucytosine • Granulocytopenia • Myelosuppression
Folate antagonists • Granulocytopenia • Inhibits folate metabolism enzyme
Trimetrexate • Pancytopenia • Blocks marrow maturation
Trimethoprim • Anemia • Ineffective hematopoiesis
Pyrimethamine • Thrombocytopenia
Pentamidine • Granulocytopenia
Ganciclovir • Granulocytopenia • Inhibits maturation of progenitor cells
• Thrombocytopenia
Sulfonamides • Anemia • Cytotoxic effect on precursor cells
Sulfamethoxazole • Granulocytopenia • Haptens elicit an immune response
Dapsone • Thrombocytopenia
Sulfadiazine • Hemolysis
Zidovudine • Anemia • Suppression of bone marrow precursor cells
• Granulocytopenia • Peripheral destruction of red blood cells