Dear Editors, Tap water therapy has been used for several decades (1) in wound cleansing for the treatment of many conditions, such as lacerations, incisions, open fractures and episiotomy (2–5). The infection rate and outcome of wounds cleansed with tap water are commonly believed to be the same as those cleaned with normal saline solution (2–5). Even though this alternative treatment is considered safe, a contrary opinion has always existed. There is still no evidence-based consensus on the contribution of tap water therapy to the treatment of wound cleansing and treatment results have not always achieved patient satisfaction. Thus, the aim of this study is to explore the safety of tap water irrigation in wound cleansing and to develop a specific recommendation based on the review of medical literature.