This document is a summary of the available toxicological information on the elements included in the recent 2006 Food Standards Agency Total Diet Study (TDS). The information in this summary has been taken from toxicological reviews including Joint FAO/WHO Expert Committee on Food Additives and Contaminants (JECFA) monologues, Environmental Health Criteria, the Expert Group on Vitamins and Minerals Report, the WHO Drinking Water Guidelines, the US EPA Integrated Risk Information System, and ATSDR toxicological profiles. Literature searches using PubMed have also been carried out in an attempt to fill in any gaps in the data and to provide more recent references where necessary. The name of each element was used as a keyword when performing a search, including any synonyms or alternative spellings. Key studies identified by the reviews used in writing this summary are mentioned where possible. This summary has focussed where possible on the oral toxicity of each of the elements.
This summary includes any conclusions resulting from previous evaluations by COT, COM, COC, JECFA and any other relevant scientific advisory committees or regulatory bodies.