In particular, Lp(a) is composed of a particle of LDL
attached to a large, hydrophilic glycoprotein, apolipoprotein A orapo(a); Apo(a) is attached to the apoB-100 of LDL by a single
disulphide bridge, but other non-covalent, hydrophobic interactions
may also occur in the association of ape(a) with LDL. Lp(a)
potentiates thrombosis, because it inhibits the binding of
plasminogen binding proteins on the surface of endothelial cells,
thus inhibiting the conversion of plasminogen to plasmin and
hence fibrinogen and fibrin degradation