The taste of fat appears to be highly regulated in mammals. The
link between taste modalities allowing the perception of high
palatable energy-dense foods and obesity is an important issue.
It appears to be reciprocal since overconsumption of energy-dense
foods promotes obesity which, in turn, disturbs sensitivity and
hedonic response to taste. A better understanding of regulatory
loops controlling the function of lipid receptors expressed in taste
buds and the subsequent gustatory pathway might open novel
avenues in the pharmacological and/or nutritional treatment of obesity.